Exercise attenuates age-associated changes in motoneuron number, nucleocytoplasmic transport proteins and neuromuscular health
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چکیده
منابع مشابه
Exercise training attenuates age-associated diastolic dysfunction in rats.
BACKGROUND In contrast to systolic function, which is relatively well preserved with advancing age, diastolic function declines steadily after age 30. Our goal was to determine whether changes in diastolic function that occur with aging could be reversed with exercise training. Methods and Results-- Adult (6-month-old) and old (24-month-old) Fischer 344/BNF1 rats were studied after either 12 we...
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The cellular basis of age-related behavioral decline remains obscure but alterations in synapses are likely candidates. Accordingly, the beneficial effects on neural function of caloric restriction and exercise, which are among the most effective anti-aging treatments known, might also be mediated by synapses. As a starting point in testing these ideas, we studied the skeletal neuromuscular jun...
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Aim of the present short review is to provide a comprehensive update on age-associated skeletal muscle damage, regeneration, and effect of endurance and resistance type of exercise training on muscle regeneration. Decrease in muscle quantity and quality leads to disability in the aging population. The degradation rate of muscle proteins during aging increased about two times, and muscle strengt...
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The cardiovascular response to ,-adrenergic stimulation is markedly blunted with advancing age, and this blunting may underlie some of the prominent age-associated changes in the hemodynamic profile during dynamic exercise. To examine this hypothesis, we administered the nonselective l3-adrenergic receptor blocker propranolol (0.15 mg/kg IV) to 25 healthy normotensive men ages 28 to 72 years fr...
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By the transplantation of amino acid-(3)H-labeled nuclei between cells and the subsequent isolation of nuclei for quantitative assay, we have confirmed that all the nuclear proteins of Amoeba proteus are divisible into two classes that are sharply defined by their physiological behavior. About 40% of the proteins in the nucleus rapidly migrates back and forth between the nucleus and the cytopla...
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ژورنال
عنوان ژورنال: GeroScience
سال: 2018
ISSN: 2509-2715,2509-2723
DOI: 10.1007/s11357-018-0020-4